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Biomarker shifts (e.g., modest reductions in inflammatory and neurodegeneration markers) were observed but did not translate into clinical benefit
Diarrhea and constipation both occur, sometimes alternating in the same individual
The recommended dosage stages for semaglutide start at 0.25 mg for four weeks, then increase to 0.5 mg for four weeks, 1.0 mg for four weeks, 1.7 mg for four weeks, with 2.4 mg as the final maintenance dose
It is recommended that the maximum duration is 2 months then taking the same duration off, so 2 months on, 2 months off
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